Congratulation to Xiao Liang! Our paper was published in Nature Chemical Biology!

Congratulation to Xiao Liang! Our paper was published in Nature Chemical Biology!

The E3 ligase TRIM7 has emerged as a critical player in viral infection and pathogenesis.We identify norovirus and SARS-CoV-2 proteins, and physiological proteins, as new TRIM7 substrates.TRIM7 could trigger the ubiquitination and degradation of these substrates, possibly representing a new Gln/C-degron pathway. These findings unveil a common recognition mode by TRIM7, providing the foundation for further mechanistic characterization of antiviral and cellular functions of TRIM7.