Key Publications
Pre-TMU
Cryo-EM structure of the RNA-guided ribonuclease Cas12g.
Li Z*, Zhang H*, Xiao RJ*, Han RJ, Chang LF#.
Nature Chemical Biology 2021
Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease.
Zhang H#*, Li Z*, Xiao RJ*, Chang LF#.
Nature Structural & Molecular Biology 2020
Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex.
Zhang H*, Devoucoux M*, Song XS, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J#, Min JR#.
Cell Reports 2020
Cryo-EM structure of a type IF CRISPR RNA guided surveillance complex bound to transposition protein TniQ.
Li Z*, Zhang H*, Xiao RJ, Chang LF#.
Cell Research 2020
Structural basis for the inhibition of CRISPR-Cas12a by anti-CRISPR proteins.
Zhang H*, Li Z*, Daczkowski CM, Clinton G, Mesecar AD, Chang LF#.
Cell Host & Microbe 2019
Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Dong C*, Zhang H*, Li L*, Tempel W, Loppnau P, Min JR#.
Nature Chemical Biology 2018
Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Zhang H*, Zhao B*, Qin S*, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min JR#.
Genes & Development 2018
Structural basis for the arginine methylation-independent recognition of PIWIL1 by TDRD2.
Zhang H*, Liu K*, Izumi N*, Huang HM, Ding DQ, Ni ZY, Sidhu SS, Chen C, Tomari Y, Min JR#.
PNAS 2017
Nucleic Acids Research 2022
A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Nature Chemical Biology 2022
2023
Structure and function of a bacterial type III-E CRISPR–Cas7-11 complex.
Yu GM*, Wang XS*, Zhang Y*, An QY*, Wen YN, Li XZ, Yin H, Deng ZQ#, Zhang H#
Nature Microbiology 2022
Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas.
Zhang H#*, Dong C*, Li L*, Wasney GA, Min JR#.
Nucleic Acids Research 2019
2022
Target RNA-guided protease activity in type III-E CRISPR–Cas system.
Wang XS*, Yu GM*, Wen YN*, An QY*, Li XZ, Liao FM, Lian CW, Zhang K, Yin H, Wei Y, Deng ZQ#, Zhang H#
Nucleic Acids Research 2022
Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8.
Yin H*, Zheng J*, He QQ*, Zhang X, Li XZ, Ma YJ, Liang X, Gao JQ, Kocsis BL, Li Z, Liu X, Alto NM, Li L#, Zhang H#
Nature Communications 2023
Structural insights into mechanisms of Argonaute protein associated NADase activation in bacterial immunity.
Wang XS*, Li XZ*, Yu GM*, Zhang LL*, Zhang CD*, Wang Y*, Liao FM, Wen YN, Yin H, Liu X, Wei Y, Li Z#, Deng ZQ#, Zhang H#
Cell Research 2023
Structural and biochemical characterization of the key components of an auxin degradation operon from the rhizosphere bacterium Variovorax.
Ma YJ*, Li XZ*, Wang F*, Zhang LL, Zhou SM, Che X, Yu DH, Liu X, Li Z#, Sun HB#, Yu GM#, Zhang H#
PLOS Biology 2023