Key Publications

Pre-TMU

Cryo-EM structure of the RNA-guided ribonuclease Cas12g.

 

Li Z*, Zhang H*, Xiao RJ*, Han RJ, Chang LF#.

 

 

Nature Chemical Biology 2021

Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease.

 

Zhang H#*, Li Z*, Xiao RJ*, Chang LF#. 

 

 

Nature Structural & Molecular Biology 2020

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex.

 

Zhang H*, Devoucoux M*, Song XS, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J#, Min JR#.

 

 

Cell Reports 2020

Cryo-EM structure of a type IF CRISPR RNA guided surveillance complex bound to transposition protein TniQ.

 

Li Z*, Zhang H*, Xiao RJ, Chang LF#. 

 

 

Cell Research 2020

Structural basis for the inhibition of CRISPR-Cas12a by anti-CRISPR proteins.

 

Zhang H*, Li Z*, Daczkowski CM, Clinton G, Mesecar AD, Chang LF#.  

 

 

Cell Host & Microbe 2019

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. 

 

Dong C*, Zhang H*, Li L*, Tempel W, Loppnau P, Min JR#.

 

 

Nature Chemical Biology 2018

Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. 

 

Zhang H*, Zhao B*, Qin S*, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min JR#. 

 

 

Genes & Development 2018

Structural basis for the arginine methylation-independent recognition of PIWIL1 by TDRD2.

 

Zhang H*, Liu K*, Izumi N*, Huang HM, Ding DQ, Ni ZY, Sidhu SS, Chen C, Tomari Y, Min JR#. 

 

 

PNAS 2017

2023

Structure and function of a bacterial type III-E CRISPR–Cas7-11 complex.

 

Yu GM*, Wang XS*, Zhang Y*, An QY*, Wen YN, Li XZ, Yin H, Deng ZQ#, Zhang H#

 

 

Nature Microbiology 2022

Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas.

 

Zhang H#*, Dong C*, Li L*, Wasney GA, Min JR#.  

 

 

Nucleic Acids Research 2019

2022

Target RNA-guided protease activity in type III-E CRISPR–Cas system.

 

Wang XS*, Yu GM*, Wen YN*, An QY*, Li XZ, Liao FM, Lian CW, Zhang K, Yin H, Wei Y, Deng ZQ#, Zhang H#

 

 

Nucleic Acids Research 2022

Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8.

 

Yin H*, Zheng J*, He QQ*, Zhang X, Li XZ, Ma YJ, Liang X, Gao JQ, Kocsis BL, Li Z, Liu X, Alto NM, Li L#, Zhang H#

 

 

Nature Communications 2023

Structural insights into mechanisms of Argonaute protein associated NADase activation in bacterial immunity.

 

Wang XS*, Li XZ*, Yu GM*, Zhang LL*, Zhang CD*, Wang Y*, Liao FM, Wen YN, Yin H, Liu X, Wei Y, Li Z#, Deng ZQ#, Zhang H#

 

 

Cell Research 2023

Structural and biochemical characterization of the key components of an auxin degradation operon from the rhizosphere bacterium Variovorax.

 

Ma YJ*, Li XZ*, Wang F*, Zhang LL, Zhou SM, Che X, Yu DH, Liu X, Li Z#, Sun HB#, Yu GM#, Zhang H#

 

 

PLOS Biology 2023

2024

Insights into the modulation of bacterial NADase activity by phage proteins.

 

Yin H*, Li XZ*, Wang XS*, Zhang CD*, Gao JQ, Yu GM, He QQ, Yang J, Liu X, Wei Y#, Li Z#, Zhang H#

 

 

Nature Communications 2024