Key Publications

Pre-TMU

Cryo-EM structure of the RNA-guided ribonuclease Cas12g.

 

Li Z#, Zhang H#, Xiao RJ#, Han RJ, Chang LF*.

 

 

Nature Chemical Biology 2021

Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease.

 

Zhang H#*, Li Z#, Xiao RJ#, Chang LF*. 

 

 

Nature Structural & Molecular Biology 2020

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex.

 

Zhang H#, Devoucoux M#, Song XS, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J*, Min JR*.

 

 

Cell Reports 2020

Cryo-EM structure of a type IF CRISPR RNA guided surveillance complex bound to transposition protein TniQ.

 

Li Z#, Zhang H#, Xiao RJ, Chang LF*. 

 

 

Cell Research 2020

Structural basis for the inhibition of CRISPR-Cas12a by anti-CRISPR proteins.

 

Zhang H#, Li Z#, Daczkowski CM, Clinton G, Mesecar AD, Chang LF*.  

 

 

Cell Host & Microbe 2019

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. 

 

Dong C#, Zhang H#, Li L#, Tempel W, Loppnau P, Min JR*.

 

 

Nature Chemical Biology 2018

Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. 

 

Zhang H#, Zhao B#, Qin S#, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min JR*. 

 

 

Genes & Development 2018

Structural basis for the arginine methylation-independent recognition of PIWIL1 by TDRD2.

 

Zhang H#, Liu K#, Izumi N#, Huang HM, Ding DQ, Ni ZY, Sidhu SS, Chen C, Tomari Y, Min JR*. 

 

 

PNAS 2017

A complete list of publications can also be found at Google Scholar.

2023

Structure and function of a bacterial type III-E CRISPR–Cas7-11 complex.

 

Yu GM#, Wang XS#, Zhang Y#, An QY#, Wen YN, Li X, Yin H, Deng ZQ*, Zhang H*.

 

 

Nature Microbiology 2022

Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas.

 

Zhang H#*, Dong C#, Li L#, Wasney GA, Min JR*.  

 

 

Nucleic Acids Research 2019

2022

Target RNA-guided protease activity in type III-E CRISPR–Cas system.

 

Wang XS#, Yu GM#, Wen YN#, An QY#, Li X, Liao FM, Lian CW, Zhang K, Yin H, Wei Y, Deng ZQ*, Zhang H*.

 

 

Nucleic Acids Research 2022

Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8.

 

Yin H#, Zheng J#, He QQ#, Zhang X, Li X, Ma YJ, Liang X, Gao JQ, Kocsis BL, Li Z, Liu X, Alto NM, Li L*, Zhang H*.

 

 

Nature Communications 2023

Structural insights into mechanisms of Argonaute protein associated NADase activation in bacterial immunity.

 

Wang XS#, Li X#, Yu GM#, Zhang LL#, Zhang CD#, Wang Y#, Liao FM, Wen YN, Yin H, Liu X, Wei Y, Li Z*, Deng ZQ*, Zhang H*.

 

 

Cell Research 2023

Structural and biochemical characterization of the key components of an auxin degradation operon from the rhizosphere bacterium Variovorax.

 

Ma YJ#, Li X#, Wang F#, Zhang LL, Zhou SM, Che X, Yu DH, Liu X, Li Z*, Sun HB*, Yu GM*, Zhang H*.

 

 

PLOS Biology 2023

2024

Insights into the modulation of bacterial NADase activity by phage proteins.

 

Yin H#, Li X#, Wang XS#, Zhang CD#, Gao JQ, Yu GM, He QQ, Yang J, Liu X, Wei Y*, Li Z*, Zhang H*.

 

 

Nature Communications 2024

Structural basis for the activity of the type VII CRISPR-Cas system.

Yang J#, Li X#, He QQ#, Wang XS#, Tang JJ#, Wang TY#, Zhang Y, Yu FY, Zhang SQ, Liu ZK, Zhang LL, Liao FM, Yin H, Zhao HY, Deng ZQ*, Zhang H*.

 

 

Nature 2024

Structural basis for the concerted antiphage activity in the SIR2–HerA system.

Liao FM#, Yu GM#, Zhang CD#, Liu ZK#, Li X, He QQ, Yin H, Liu X, Li Z*, Zhang H*.

Nucleic Acids Research 2024

Structural basis for the type I-F Cas8-HNH system.

Li X#, Liu YN#, Han J#, Zhang LL#, Liu ZK, Wang L, Zhang SQ, Zhang Q, Fu PY, Yin H, Zhu HT*, Zhang H*.

 

The EMBO Journal 2024